Blow Fill Seal Packaging Blow fill seal is a unique packaging technique that can produce liquid filling containers of small and large size and shape. The BFS technique was introduced in the United States in the 1960s, but over the past two decades it has become more common and convenient in the pharmaceutical industry and is now widely considered the superior form of aseptic processing by various drug regulatory agencies, including The U.S. Food and Drug Administration (FDA) in the packaging of pharmaceutical and healthcare products. The concept behind BFS is that a container is formed, filled and sealed in a continuous process without human intervention, in a sterile enclosed area inside a machine. Therefore this technology can be useful in aseptic manufacturing processes and in the aseptic production of sterile pharmaceutical liquid dosage forms. The BFS technique is cheaper than other common techniques and saves a lot of time and labor. Blow Fill Seal technology reduces staff intervention making it a more robust method for aseptic preparation of pharmaceutical products and sterile packaging. BFS is used for filling vials for parenteral preparations and infusions, eye drops and inhalation products. Generally plastic containers are made of polyethylene and polypropylene. Polypropylene is most commonly used to form autoclaved containers as polypropylene has greater thermostability. BFS is a multi-step process. Each step is unique in itself. At first the pharmaceutical grade plastic resin is extruded vertically while hot using a circular throat, to form a suspended tube called Parison. This extruded tube is then enclosed inside a two-part mold and the tube is cut above the mold. After ...... half of the paper ......d to its final thermal condition. Another feature provided by initially outwardly bulged panels that are reconfigured to an inwardly collapsed position is that each panel causes a rather large change in volume thus decreasing the number of panels needed compared to that provided by panels that are initially configured to be concave. Reducing the number of panels or the proportion of surface area covered by those panels means that greater support can be given to any labels applied to the container on those panels. These and other features and advantages of the present invention will become apparent to those skilled in the art in consideration of the following detailed description of preferred embodiments which exemplify the best mode of carrying out the invention as currently perceived. The detailed description refers in particular to the attached drawings.