This comprehensive literature review is based on analysis and research conducted on autism spectrum disorder (ASD), a brain development disorder characterized by difficulties in social interaction, verbal and non-verbal communication and repetitive behaviors. Social problems include less attention to social stimuli, less eye contact, and learning difficulties. The communication problem is due to a significant delay in language development as it affects information processing in the brain by altering the way nerve cells and their synapses connect and organize. Since the symptoms characterized by each affected individual are unique, it is coined as a “spectrum disorder”. This comprehensive literature review spans topics involving neighborhood deprivation, stress, behavior, quality of life among individuals with autism and their families along with biological factors. factors involved in the autistic group. There is no cure for autism, however research ideas and article summaries are included in an effort to complete the knowledge about autism. Neurological connections have also been established to understand the complex nature of this disorder.2. BACKGROUNDIt was Eugen Bleuler who coined the word "autism" in schizophrenic patients who were egocentric. The beginnings of autism analysis date back to 1939 as an extension of psychoanalysis, a method developed by Sigmund Freud. Psychoanalysis was used primarily in the therapeutic treatment of psychological disorders and thus extended to autism, which is also characterized by brain disorders. Leo Kanner, a psychiatrist at John Hopkins University, first established the term "Early Infantile Autism" which he described as a distinct neurological condition... halfway through the paper... had 6% more brain volume than those who they didn't have autism. Latefa A. Dardas and Muayyad M. Ahmad from the University of Jordan discussed extensively about quality of life (QoL) among parents of children with autistic disorder. The purposes of this study were: (1) to examine differences in quality of life between fathers and mothers of children with autistic disorder in a sample from an Arab country, and (2) to examine the psychosocial correlates of quality of life in children with autism. autistic disorder Arab parents of children with autistic disorder. The results showed no significant differences in the physical, psychological, social and environmental health of fathers and mothers of children with autistic disorder. Furthermore, both parents showed almost similar bivariate correlations between reported QoL levels and their parenting stress, coping strategies, and demographic characteristics...