Osteoarthritis has been studied extensively throughout history and around the world. There are multiple possible solutions to relieve the pain caused by cartilage depletion, although no cure has been found. Osteoarthritis is a degenerative disease and is idiopathic. The first theme consists of the results of a study conducted by Felson and Nevitt, who discovered the effects of estrogen on osteoarthritis. This study highlights how osteoarthritis is more frequent in women than in men, since menopause causes a significant loss of estrogen. They demonstrated this by comparing animal studies with those on humans. Animal studies have found that when ovariectomized animals are given estrogen replacement therapy, the disease is prevented from progressing (Felson & Nevitt, 1998). Through animal studies, estrogen replacement therapy has become an extraordinary medical breakthrough and is useful for those individuals who primarily lose a significant amount of estrogen during menopause. Another issue is age, a factor when dealing with osteoarthritis that is found predominantly in patients over the age of sixty-five (Straub, Wolff, Fassold, Hofbauer, Chover-Gonzalez, Richards and Jessop, 2008). However, Felson and Nevitt (1998) found that women are more likely to be diagnosed with osteoarthritis due to the decrease in estrogen after menopause. Menopause usually occurs in the female population around the age of fifty and can last months or even years depending on the individual. During this period of time, the decrease in estrogen, which is a hormone vital for bone growth, aggravates the onset of osteoarthritis. of the article......on Hyponosis and Jacobson's relaxation. European Journal of Pain, 30(5), 1-17. Gordon, A., Callaghan, D., & Spink, D. (2010). Buprenorphine transdermal system in adults with chronic low back pain: a randomized, double-blind, placebo-controlled crossover study followed by an open-label extension phase. Clinical Therapeutics, 32(5), 844-860.Jessop, D.S., Fassold, A., Wolff, C., Hofbauer, R., Chover-Gonzalez, A., Richards, L.J. and Straub, R.H. (2010), Endomorphins in rheumatoid arthritis, osteoarthritis and experimental arthritis. Annals of the New York Academy of Sciences, 1193(2), 117–122.Straub, R.H., Wolff, C., Fassold, A., Hofbauer, R., Chover-Gonzalez, A., Richards, L.J., and Jessop , DS (2008), Anti-inflammatory role of endomorphins in osteoarthritis, rheumatoid arthritis and adjuvant-induced polyarthritis. Arthritis and rheumatism, 58(2), 456–466.