Developments in nanotechnology and tissue engineering have provided promising methods for repairing and replacing damaged bone [3, 4]. Poly(sorbital sebacate adipate) (PSSA) is a fully biodegradable thermoplastic aliphatic polyester with biocompatibility and eco-safety. However, it has some drawbacks, such as high elongations and very low thermal stability, which prevent wider commercial applications. The mechanical and thermal instability of the PSSA elastomer prevents it from replacing biodegradable nanomaterials in commercial products [3]. To overcome these drawbacks of PSSA, we prepared organically modified PSSA nanocomposites [4]. Human bone tissue is a nanocomposite with both organic and inorganic components. In particular, mineralized hydroxyapatite [Ca10(PO4)6(OH)2,] which is the main inorganic constituent of the bone extracellular matrix. In general, a perfect tissue engineering composite should ensure several necessary criteria. It should be: biocompatible with the structure and chemistry of the biomimetic nanosurface to minimize local tissue response while maximizing cell growth and tissue integration; porous to allow cell passage and well-organized exchange of nutrients and waste; biodegradable with a favorable degradation rate, which allows the composite to provide structural support for initial cell growth and then gradually degrade after new tissue formation; and possess adequate mechanical properties to support tissue growth under native mechanical loads.[2,5–7].Polymer nanocomposites are commonly defined as the combination of a polymer matrix and fillers that have at least one dimension (i.e., length, width, or furthermore, PSSA/HAP composites have thickness) in the nanometer si...... at the center of the paper ...... awaiting their biological cellular responses. Herein, we reported the synthesis of SWCNTs-M-HAP/PSSA nanocomposites with variable amount of SWCNTs-M-HAP by in situ hydrothermal method. The friction coefficients of SWCNTs-M-HAP composites were evaluated using the UMT-2 friction tester. In particular, we discuss in detail the effect of several factors, including the content of SWCNTs-M-HAP, which alter the mechanical, biological, thermal, and structural properties of the PSSA elastomer. For comparison purposes, the friction coefficient of the pure PSSA elastomer was also analyzed. We found that the addition of SWCNTs-M-HAP into the composite can decrease the friction coefficient of the composite compared to pure PSSA. The friction coefficient of the composite gradually decreases with the increase of SWCNTs-M-HAP content in the composite and increases with the increase of the applied load.